High school student Suzuko Homura returned to Ikebukuro, the city where she grew up. The girl carefully keeps memories of her childhood friend, Tinatsu Morikave, and is delighted with the prospect of meeting her again. However, when Suzuko enters a new school, she discovers problems in communicating with the class. To solve them and make friends, the heroine intends to learn how to play the popular card game "WIXOSS". Entering the card store on the way home, Suzuko buys a set of cards. When she opens it at home, the girl on one of the cards starts to move and talk. And she says this: people selected as selectors must fight for control over the five coins that store all their memories. If they can regain all the coins, they will win and be able to exit the game. But if they lose - they are waiting for "Lostrej". What will become of Suzuko and such as she is in this crazy game? Meanwhile, like Suzuko , Tinatsu turns out to be drawn into this game ...